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新白叶藤碱衍生物 Z24对灰葡萄孢菌的作用机制及靶标研究
学位论文
理学博士, 兰州: 兰州大学, 2023
Authors:
赵文斌
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  |  
  
Submit date:2023/11/15
新白叶藤碱衍生物Z24
neocryptolepine derivative Z24
灰葡萄孢菌
B. cinerea
分子靶标
molecular target
硫胺噻唑合酶
thiaminothiazole synthase
可变剪接
variable splicing
硫胺素代谢
thiamine metabolism
虚拟筛选
virtual screening
Identification of Potential Novel B-Cell Epitopes of Capsid Protein VP2 in Senecavirus A
期刊论文
Microbiology Spectrum, 2023, 卷号: 11, 期号: 4
Authors:
Ru, Yi
;
Hao, Rongzeng
;
Wu, Chunping
;
Li, Yajun
;
Lu, Bingzhou
;
Liu, Huanan
;
Tian, Hong
;
Li, Dan
;
Shi, Zhengwang
;
Luo, Juncong
...
Ru, Yi
;
Hao, Rongzeng
;
Wu, Chunping
;
Li, Yajun
;
Lu, Bingzhou
;
Liu, Huanan
;
Tian, Hong
;
Li, Dan
;
Shi, Zhengwang
;
Luo, Juncong
;
Ma, Kun
;
Zhang, Guicai
;
Liu, Xiangtao
;
Zheng, Haixue
Favorite
  |  
  
Submit date:2023/11/28
senecavirus A
SVA
VP2 protein
immunodominant epitope
Pepscan
Protein target highlights in CASP15: Analysis of models by structure providers
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2023
Authors:
Alexander, Leila T.
;
Durairaj, Janani
;
Kryshtafovych, Andriy
;
Abriata, Luciano A.
;
Bayo, Yusupha
;
Bhabha, Gira
;
Breyton, Cecile
;
Caulton, Simon G.
;
Chen, James
;
Degroux, Seraphine
...
Alexander, Leila T.
;
Durairaj, Janani
;
Kryshtafovych, Andriy
;
Abriata, Luciano A.
;
Bayo, Yusupha
;
Bhabha, Gira
;
Breyton, Cecile
;
Caulton, Simon G.
;
Chen, James
;
Degroux, Seraphine
;
Ekiert, Damian C.
;
Erlandsen, Benedikte S.
;
Freddolino, Peter L.
;
Gilzer, Dominic
;
Greening, Chris
;
Grimes, Jonathan M.
;
Grinter, Rhys
;
Gurusaran, Manickam
;
Hartmann, Marcus D.
;
Hitchman, Charlie J.
;
Keown, Jeremy R.
;
Kropp, Ashleigh
;
Kursula, Petri
;
Lovering, Andrew L.
;
Lemaitre, Bruno
;
Lia, Andrea
;
Liu, Shiheng
;
Logotheti, Maria
;
Lu, Shuze
;
Markusson, Sigurbjorn
;
Miller, Mitchell D.
;
Minasov, George
;
Niemann, Hartmut H.
;
Opazo, Felipe
;
Phillips Jr, George N. N.
;
Davies, Owen R.
;
Rommelaere, Samuel
;
Rosas-Lemus, Monica
;
Roversi, Pietro
;
Satchell, Karla
;
Smith, Nathan
;
Wilson, Mark A.
;
Wu, Kuan-Lin
;
Xia, Xian
;
Xiao, Han
;
Zhang, Wenhua
;
Zhou, Z. Hong
;
Fidelis, Krzysztof
;
Topf, Maya
;
Moult, John
;
Schwede, Torsten
Favorite
  |  
  
Submit date:2023/11/28
CASP
cryo-EM
protein structure prediction
X-ray crystallography
利用超声靶向微泡破坏技术沉默 PDLIM5 探索非小细胞性 肺癌自噬与耐药关系的实验研究
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
张瑶
Favorite
  |  
  
Submit date:2023/11/15
非小细胞性肺癌
Non-small-cell lung cancer (NSCLC)
肿瘤细胞耐药
Drug resistance of tumor cell
超声微泡靶向破坏技术
Ultrasound targeted microbubble destruction (UTMD)
纳米材料
nanomaterials
PDLIM5
PDLIM5
细胞自噬
autophagy
基因沉默
gene silencing
基于网络药理学探究五味子乙素通过Nrf2/HO-1信号通路干预小鼠肠缺血再灌注损伤机制的实验研究
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
侯小煜
Favorite
  |  
  
Submit date:2023/11/15
网络药理学
Network pharmacology, Schisandrin B, Intestinal ischemia reperfusion injury, Apoptosis, Nrf2/HO-1 pathway
五味子乙素
肠缺血再灌注损伤
凋亡
Nrf2/HO-1信号通路
茄科马尿泡高海拔适应与演化的基因组学研究
学位论文
理学博士, 兰州: 兰州大学, 2023
Authors:
武颖
Favorite
  |  
  
Submit date:2023/11/15
青藏高原
Qinghai-Tibet Plateau
高海拔适应
high altitude adaptation
兼性繁育系统
facultative breeding system
趋同演化
convergent evolution
创新性状
innovative trait
用于蛋白-小分子亲和力预测的蛋白质表示学习方法研究
学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:
卢瑞强
Favorite
  |  
  
Submit date:2023/11/15
蛋白-分子亲和力预测
Protein-Ligand Affinity Prediction
蛋白质表示学习
Protein Representation Learning
深度学习
Deep Learning
虚拟筛选
Virtual Screening
基于结构相似度和深度学习模型预测化合物绑定靶蛋白的研究
学位论文
工程硕士, 兰州: 兰州大学, 2023
Authors:
石亚蓉
Favorite
  |  
  
Submit date:2023/11/15
深度学习
Deep learning
神经网络
Neural Network
化合物绑定靶蛋白
Compound-Target Binding
结构相似度
Structural Similarity
香豆素类 BRD4 抑制剂的 设计合成及生物活性研究
学位论文
药学硕士, 兰州: 兰州大学, 2023
Authors:
崔起航
Favorite
  |  
  
Submit date:2023/11/15
溴结构域蛋白 4
BRD4
香豆素
coumarin,
抑制剂
inhibitor,
抗肿瘤
antitumor
黄杆菌LV-1还原六价铬的机理及铬还原蛋白的筛选
学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:
吕伟
Favorite
  |  
  
Submit date:2023/11/15
六价铬污染
Cr(VI) pollution,
黄杆菌
Flavobacterium
六价铬还原菌
Hexavalent chromium reducing bacteria
铬还原酶
Chromate reductase
酶活反应
Enzymatic reaction