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兰州大学机构库

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Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2023
Authors:  Dong, Jiale;  Xiao, Jing;  Li, Jianyi;  Yu, Huan;  Zhao, Qian;  Tang, Qinglin;  Chen, Hui;  Liu, Han;  Wu, Kejue;  Lei, Jinping...Dong, Jiale;  Xiao, Jing;  Li, Jianyi;  Yu, Huan;  Zhao, Qian;  Tang, Qinglin;  Chen, Hui;  Liu, Han;  Wu, Kejue;  Lei, Jinping;  Wang, Rui;  Jiang, Xianxing
Favorite  |    Submit date：2023/07/18
Different Performances of BF3, BCl3, and BBr3 in Hypervalent Iodine-Catalyzed Halogenations 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 88, 期号: 7, 页码: 4359-4371
Authors:  Qin, Yuji;  Qi, Liang;  Zhen, Xiang;  Wang, Xueqing;  Chai, Hongli;  Ma, Xingyu;  Jiang, Xianxing;  Cai, Xiaoqing;  Zhu, Weiwei
Favorite  |    Submit date：2023/05/25
Bromine compounds  Catalysis  Chlorine compounds  Iodine  Reaction intermediates  2-oxazoline  Activated alkenes  Activating reagents  Higher yield  Hypervalent iodine  Ligand coupling  Oxidative additions  Performance  Reaction pathways  Reactive intermediate  
Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs-EBP interaction recover NAFLD through enhancing mitochondrial function in mice 期刊论文
Acta Pharmaceutica Sinica B, 2023, 卷号: 13, 期号: 2, 页码: 542-558
Authors:  Song, Nazi;  Xu, Hongjiao;  Wu, Shuohan;  Luo, Suijia;  Xu, Jingyao;  Zhao, Qian;  Wang, Rui;  Jiang, Xianxing
Favorite  |    Submit date：2023/04/12
NASH  Liver fibrosis  Combination therapy  Mitochondrial function  Mitophagy  Mitochondrial biogenesis  AMPK  EDPs  AdipoR1  2 agonist  
Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis 期刊论文
Acta Pharmaceutica Sinica B, 2022, 卷号: 12, 期号: 5, 页码: 2443-2461
Authors:  Song, Nazi;  Xu, Hongjiao;  Liu, Jiahua;  Zhao, Qian;  Chen, Hui;  Yan, Zhibin;  Yang, Runling;  Luo, Zhiteng;  Liu, Qi;  Ouyang, Jianmei...Song, Nazi;  Xu, Hongjiao;  Liu, Jiahua;  Zhao, Qian;  Chen, Hui;  Yan, Zhibin;  Yang, Runling;  Luo, Zhiteng;  Liu, Qi;  Ouyang, Jianmei;  Wu, Shuohan;  Luo, Suijia;  Ye, Shuyin;  Lin, Runfeng;  Sun, Xi;  Xie, Junqiu;  Lan, Tian;  Wu, Zhongdao;  Wang, Rui;  Jiang, Xianxing
Favorite  |    Submit date：2022/07/01
GLP-1R  GCGR  Liver fibrosis  Inflammation  Apoptosis  Candidate peptides  
Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis 期刊论文
Acta Pharmaceutica Sinica B, 2022, 卷号: 12, 期号: 5, 页码: 2443-2461
Authors:  Song, Nazi;  Xu, Hongjiao;  Liu, Jiahua;  Zhao, Qian;  Chen, Hui;  Yan, Zhibin;  Yang, Runling;  Luo, Zhiteng;  Liu, Qi;  Ouyang, Jianmei...Song, Nazi;  Xu, Hongjiao;  Liu, Jiahua;  Zhao, Qian;  Chen, Hui;  Yan, Zhibin;  Yang, Runling;  Luo, Zhiteng;  Liu, Qi;  Ouyang, Jianmei;  Wu, Shuohan;  Luo, Suijia;  Ye, Shuyin;  Lin, Runfeng;  Sun, Xi;  Xie, Junqiu;  Lan, Tian;  Wu, Zhongdao;  Wang, Rui;  Jiang, Xianxing
Favorite  |    Submit date：2022/07/25
GLP-1R  GCGR  Liver fibrosis  Inflammation  Apoptosis  Candidate peptides  
A CDR-based approach to generate covalent inhibitory antibody for human rhinovirus protease 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 42
Authors:  Cheng, Yaping;  Wu, Jingyuan;  Han, Ying;  Xu, Jingyao;  Da, Yifan;  Zhao, Qian;  Guo, Guoying;  Zhou, Yani;  Chen, Yimin;  Liu, Jinghong...Cheng, Yaping;  Wu, Jingyuan;  Han, Ying;  Xu, Jingyao;  Da, Yifan;  Zhao, Qian;  Guo, Guoying;  Zhou, Yani;  Chen, Yimin;  Liu, Jinghong;  Chen, Huayao;  Jiang, Xianxing;  Cai, Xiaoqing
Favorite  |    Submit date：2021/08/12
CDR-H3  Covalent inhibition  Inhibitory antibody  Intracellular screening  Protease 3C  Proximity-enabled bioactivity  
Catalytic asymmetric nucleophilic fluorination using BF3 center dot Et2O as fluorine source and activating reagent 期刊论文
Nature Communications, 2021, 卷号: 12, 期号: 1
Authors:  Zhu, Weiwei;  Zhen, Xiang;  Wu, Jingyuan;  Cheng, Yaping;  An, Junkai;  Ma, Xingyu;  Liu, Jikun;  Qin, Yuji;  Zhu, Hao;  Xue, Jijun...Zhu, Weiwei;  Zhen, Xiang;  Wu, Jingyuan;  Cheng, Yaping;  An, Junkai;  Ma, Xingyu;  Liu, Jikun;  Qin, Yuji;  Zhu, Hao;  Xue, Jijun;  Jiang, Xianxing
Favorite  |    Submit date：2021/12/15
Catalytic asymmetric nucleophilic fluorination using BF3•Et2O as fluorine source and activating reagent 期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1
Authors:  Zhu, Weiwei;  Zhen, Xiang;  Wu, Jingyuan;  Cheng, Yaping;  An, Junkai;  Ma, Xingyu;  Liu, Jikun;  Qin, Yuji;  Zhu, Hao;  Xue, Jijun...Zhu, Weiwei;  Zhen, Xiang;  Wu, Jingyuan;  Cheng, Yaping;  An, Junkai;  Ma, Xingyu;  Liu, Jikun;  Qin, Yuji;  Zhu, Hao;  Xue, Jijun;  Jiang, Xianxing
Favorite  |    Submit date：2023/12/01
The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis 期刊论文
Acta Pharmaceutica Sinica B, 2021, 卷号: 11, 期号: 1, 页码: 100-111
Authors:  Yan, Zhibin;  Wang, Dan;  An, Chunmei;  Xu, Hongjiao;  Zhao, Qian;  Shi, Ying;  Song, Nazi;  Deng, Bochuan;  Guo, Xiaomin;  Rao, Jing...Yan, Zhibin;  Wang, Dan;  An, Chunmei;  Xu, Hongjiao;  Zhao, Qian;  Shi, Ying;  Song, Nazi;  Deng, Bochuan;  Guo, Xiaomin;  Rao, Jing;  Cheng, Lu;  Zhang, Bangzhi;  Mou, Lingyun;  Yang, Wenle;  Jiang, Xianxing;  Xie, Junqiu
Favorite  |    Submit date：2021/04/16
Liver fibrosis  Inflammation  Antimicrobial peptide  MiR-155  CASP12  
AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis 期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1
Authors:  Xu, Hongjiao;  Zhao, Qian;  Song, Nazi;  Yan, Zhibin;  Lin, Runfeng;  Wu, Shuohan;  Jiang, Lili;  Hong, Sihua;  Xie, Junqiu;  Zhou, Huihao...Xu, Hongjiao;  Zhao, Qian;  Song, Nazi;  Yan, Zhibin;  Lin, Runfeng;  Wu, Shuohan;  Jiang, Lili;  Hong, Sihua;  Xie, Junqiu;  Zhou, Huihao;  Wang, Rui;  Jiang, Xianxing
Favorite  |    Submit date：2023/12/04