兰州大学机构库

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Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 9, 页码: 3959-3962
Authors:  Yang, CJ;  Song, ZL;  Goto, M;  Liu, YQ;  Hsieh, KY;  Morris-Natschke, SL;  Zhao, YL;  Zhang, JX;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA....Yang, CJ;  Song, ZL;  Goto, M;  Liu, YQ;  Hsieh, KY;  Morris-Natschke, SL;  Zhao, YL;  Zhang, JX;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.
Favorite  |    Submit date:2018/09/28
Camptothecin  Cytotoxic activity  Piperazine  Sulfonylamidine  Synthesis  
Synthesis and biological evaluation of novel spin labeled 18 beta-glycyrrhetinic acid derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 24, 页码: 7530-7533
Authors:  Liu, YQ(刘映前);  Qian, KD;  Wang, CY;  Chen, CH;  Yang, XM;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.
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Spin-labeled  18 beta-Glycyrrhetinic acid  Nitroxide  Cytotoxicity  20S proteasome inhibitors  
Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 20, 页码: 4694-4697
Authors:  Yang, CJ;  Song, ZL;  Goto, M;  Hsu, PL;  Zhang, XS;  Yang, QR;  Liu, YQ;  Wang, MJ;  Morris-Natschke, SL;  Shang, XF...Yang, CJ;  Song, ZL;  Goto, M;  Hsu, PL;  Zhang, XS;  Yang, QR;  Liu, YQ;  Wang, MJ;  Morris-Natschke, SL;  Shang, XF;  Lee, KH;  Liu, YQ (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China.;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.
Favorite  |    Submit date:2018/09/28
Camptothecin  Cytotoxic activity  Fluorination  Synthesis  
Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 75, 页码: 282-288
Authors:  Kou, L;  Wang, MJ;  Wang, LT;  Zhao, XB;  Nan, X;  Yang, L;  Liu, YQ(刘映前);  Morris-Natschke, SL;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA....Kou, L;  Wang, MJ;  Wang, LT;  Zhao, XB;  Nan, X;  Yang, L;  Liu, YQ(刘映前);  Morris-Natschke, SL;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.
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Podophyllotoxin  C-4 position  Spin labeled  Isocyanide multicomponent reactions  Cytotoxic activity  
Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 8, 页码: 1750-1753
Authors:  Zhu, GX;  Cheng, PL;  Goto, M;  Zhang, N;  Morris-Natschke, SL;  Hsieh, KY;  Yang, GZ;  Yang, QR;  Liu, YQ;  Chen, HL...Zhu, GX;  Cheng, PL;  Goto, M;  Zhang, N;  Morris-Natschke, SL;  Hsieh, KY;  Yang, GZ;  Yang, QR;  Liu, YQ;  Chen, HL;  Zhang, XS;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.
Favorite  |    Submit date:2018/01/19
Camptothecin  Cytotoxic activity  Sulfonylpiperazine  Synthesis  
Perspectives on Biologically Active Camptothecin Derivatives 期刊论文
MEDICINAL RESEARCH REVIEWS, 2015, 卷号: 35, 期号: 4, 页码: 753-789
Authors:  Liu, YQ;  Li, WQ;  Morris-Natschke, SL;  Qian, KD;  Yang, L;  Zhu, GX;  Wu, XB;  Chen, AL;  Zhang, SY;  Nan, X...Liu, YQ;  Li, WQ;  Morris-Natschke, SL;  Qian, KD;  Yang, L;  Zhu, GX;  Wu, XB;  Chen, AL;  Zhang, SY;  Nan, X;  Lee, KH;  Lee, KH (reprint author), Univ N Carolina, Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA.
Favorite  |    Submit date:2017/01/11
camptothecins  DNA topoisomerase I  biological activities  structure-activity relationship  
Development and Preclinical Studies of Broad-Spectrum Anti-HIV Agent (3 ' R,4 ' R)-3-Cyanomethyl-4-methyl-3 ',4 '-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-Cyanomethyl-4-methyl-DCK) 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 卷号: 51, 期号: 24
Authors:  Xie, L;  Guo, HF;  Lu, H;  Zhuang, XM;  Zhang, AM;  Wu, G;  Ruan, JX;  Zhou, T;  Yu, D;  Qian, K...Xie, L;  Guo, HF;  Lu, H;  Zhuang, XM;  Zhang, AM;  Wu, G;  Ruan, JX;  Zhou, T;  Yu, D;  Qian, K;  Lee, KH;  Jiang, S;  Xie, L (reprint author), Beijing Inst Pharmacol & Toxicol, 27 Taiping Rd, Beijing 100850, Peoples R China.
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Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 25, 期号: 13, 页码: 2690-2693
Authors:  Song, ZL;  Chen, HL;  Wang, YH;  Goto, M;  Gao, WJ;  Cheng, PL;  Morris-Natschke, SL;  Liu, YQ;  Zhu, GX;  Wang, MJ...Song, ZL;  Chen, HL;  Wang, YH;  Goto, M;  Gao, WJ;  Cheng, PL;  Morris-Natschke, SL;  Liu, YQ;  Zhu, GX;  Wang, MJ;  Lee, KH;  Liu, YQ (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.
Favorite  |    Submit date:2017/01/11
Camptothecin  C-20 position  Cytotoxic activity  Poly(ethylene glycol) (PEG)  Sulfonylamidine