兰州大学机构库

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多肽新药研发策略研究进展 期刊论文
中国科学. 化学, 2013, 期号: 8, 页码: 5-8
Authors:  张伟;  宋竟婧;  张邦治;  杨雯乐;  王锐
Favorite  |    Submit date:2016/09/09
多肽药物  神经肽  抗菌肽  靶向肽  穿膜肽  
Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa 期刊论文
AMINO ACIDS, 2018, 卷号: 50, 期号: 10, 页码: 1471-1483
Authors:  Xie, JQ(谢俊秋);  Li, Yao;  Li, Jing;  Yan, Zhibin;  Wang, Dan;  Guo, Xiaomin;  Zhang, Jianfeng;  Zhang, BZ(张邦治);  Mou, Lingyun;  Yang, WL(杨雯乐)...Xie, JQ(谢俊秋);  Li, Yao;  Li, Jing;  Yan, Zhibin;  Wang, Dan;  Guo, Xiaomin;  Zhang, Jianfeng;  Zhang, BZ(张邦治);  Mou, Lingyun;  Yang, WL(杨雯乐);  Jiang, Xianxing
Favorite  |    Submit date:2019/11/04
Pseudomonas aeruginosa  Antimicrobial peptides  Analogs  Multidrug-resistant bacteria  Anti-biofilm  
Enantioselective Dearomative Arylation of Isoquinolines 期刊论文
ACS Catalysis, 2016, 卷号: 6, 期号: 8, 页码: 5290-5294
Authors:  Zhang, Ming;  Sun, WS(孙旺盛);  Zhu, Gongming;  Bao, Guangjun;  Zhang, BZ(张邦治);  Hong, Liang;  Li, Min;  Wang, R(王锐)
Favorite  |    Submit date:2017/01/10
enantioselective  isoquinolines  dearomative arylation  indole  chiral phosphoric acid  
Feleucin-K3 Analogue with an alpha-(4-Pentenyl)-Ala Substitution at the Key Site Has More Potent Antimicrobial and Antibiofilm Activities in Vitro and in Vivo 期刊论文
ACS Infectious Diseases, 2021, 卷号: 7, 期号: 1, 页码: 64-78
Authors:  Guo, Xiaomin;  Rao, Jing;  Yan, Tiantian;  Zhang, BZ(张邦治);  Yang, WL(杨雯乐);  Sun, WS(孙旺盛);  Xie, JQ(谢俊秋)
Favorite  |    Submit date:2021/04/16
antimicrobial peptides analogues  unnatural hydrophobic amino acid  alpha-(4-Pentenyl)-Ala  antimicrobial activity  antibiofilm activity  
Feleucin-K3 Analogue with an α-(4-Pentenyl)-Ala Substitution at the Key Site Has More Potent Antimicrobial and Antibiofilm Activities in Vitro and in Vivo 期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 1, 页码: 64-78
Authors:  Guo, Xiaomin;  Rao, Jing;  Yan, Tiantian;  Zhang, BZ(张邦治);  Yang, WL(杨雯乐);  Sun, WS(孙旺盛);  Xie, JQ(谢俊秋)
Favorite  |    Submit date:2023/12/01
antimicrobial peptides analogues  unnatural hydrophobic amino acid  alpha-(4-Pentenyl)-Ala  antimicrobial activity  antibiofilm activity  
Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista 期刊论文
PEPTIDES, 2013, 卷号: 39, 页码: 80-88
Authors:  Wang, KR;  Yan, JX;  Dang, W;  Liu, X;  Chen, R;  Zhang, JD;  Zhang, BZ(张邦治);  Zhang, W;  Kai, M;  Yan, WJ...Wang, KR;  Yan, JX;  Dang, W;  Liu, X;  Chen, R;  Zhang, JD;  Zhang, BZ(张邦治);  Zhang, W;  Kai, M;  Yan, WJ;  Yang, ZB;  Xie, JQ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Life Sci, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci,Inst Biochem & Mol Biol, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
Adobe PDF(1597Kb)  |  Favorite  |    Submit date:2015/12/14
Resistant bacteria  Polybia-MPI  Membrane perturbation  Molecular dynamics study  
Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social wasp Polybia paulista 期刊论文
TOXICOLOGY, 2011, 卷号: 288, 期号: 1-3, 页码: 27-33
Authors:  Wang, KR;  Yan, JX;  Liu, X;  Zhang, JD;  Chen, R;  Zhang, BZ(张邦治);  Dang, W;  Zhang, W;  Kai, M;  Song, JJ...Wang, KR;  Yan, JX;  Liu, X;  Zhang, JD;  Chen, R;  Zhang, BZ(张邦治);  Dang, W;  Zhang, W;  Kai, M;  Song, JJ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Biochem & Mol Biol, Key Lab Preclin Study New Drugs Gansu Prov, 199 Western Donggang Rd, Lanzhou 730000, Peoples R China.
Adobe PDF(1337Kb)  |  Favorite  |    Submit date:2015/12/22
Antimicrobial peptide  Polybia-CP  Molecular dynamics simulations  Membrane perturbation  "Carpet" model  
Cellular uptake of transportan 10 and its analogs in live cells: Selectivity and structure-activity relationship studies 期刊论文
PEPTIDES, 2011, 卷号: 32, 期号: 9, 页码: 1934-1941
Authors:  Song, JJ;  Kai, M;  Zhang, W;  Zhang, JD;  Liu, LW;  Zhang, BZ(张邦治);  Liu, X;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
Adobe PDF(755Kb)  |  Favorite  |    Submit date:2015/12/22
Cell penetrating peptide  Structure-activity relationship  Uptake selectivity  Molecular dynamics simulations  
Design of an Acid-Activated Antimicrobial Peptide for Tumor Therapy 期刊论文
MOLECULAR PHARMACEUTICS, 2013, 卷号: 10, 期号: 8, 页码: 2934-2941
Authors:  Song, JJ;  Zhang, W;  Kai, M;  Chen, JB;  Liang, RR;  Zheng, X;  Li, GL;  Zhang, BZ(张邦治);  Wang, KR;  Zhang, Y...Song, JJ;  Zhang, W;  Kai, M;  Chen, JB;  Liang, RR;  Zheng, X;  Li, GL;  Zhang, BZ(张邦治);  Wang, KR;  Zhang, Y;  Yang, ZB;  Ni, JM(倪京满);  Wang, R(王锐);  Ni, JM (reprint author), Lanzhou Univ, Sch Pharm, 222 South Tianshui Rd, Lanzhou 730000, Peoples R China.
Adobe PDF(553Kb)  |  Favorite  |    Submit date:2015/12/22
antimicrobial peptide  antitumor  acid activate  low toxicity  enzymatic stability  
A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice 期刊论文
PEPTIDES, 2010, 卷号: 31, 期号: 10, 页码: 1832-1838
Authors:  Zhang, W;  Li, J;  Liu, LW;  Wang, KR;  Song, JJ;  Yan, JX;  Li, ZY;  Zhang, BZ(张邦治);  Wang, R(王锐);  Zhang, BZ (reprint author), Lanzhou Univ, Inst Biochem & Mol Biol, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Gansu, Peoples R China....Zhang, W;  Li, J;  Liu, LW;  Wang, KR;  Song, JJ;  Yan, JX;  Li, ZY;  Zhang, BZ(张邦治);  Wang, R(王锐);  Zhang, BZ (reprint author), Lanzhou Univ, Inst Biochem & Mol Biol, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Gansu, Peoples R China.
Adobe PDF(580Kb)  |  Favorite  |    Submit date:2015/12/22
Antimicrobial peptide  Anticancer  Thioamide  Enzymatic stability  Toxicity