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兰州大学机构库

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Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256
Authors:  Wang, Yuqing;  Long, Lin;  Zhuo, Linsheng;  Zhang, Honghua;  Luo, Tian;  Deng, Jiedan;  Wang, Yuying;  Li, Zhao;  Wang, Zhen;  Peng, Xue...Wang, Yuqing;  Long, Lin;  Zhuo, Linsheng;  Zhang, Honghua;  Luo, Tian;  Deng, Jiedan;  Wang, Yuying;  Li, Zhao;  Wang, Zhen;  Peng, Xue
Favorite  |    Submit date：2023/07/18
Hepatocellular carcinoma  Mitochondria  1-Styryl isoquinoline  Resveratrol  Apoptosis  
N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubuli- n-Inhibiting anti-gastrointestinal tumor agents 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 255
Authors:  Deng, Jiedan;  Long, Lin;  Peng, Xue;  Jiang, Weifan;  Peng, Ying;  Zhang, Xi;  Zhao, Yuting;  Tian, Ying;  Wang, Zhen;  Zhuo, Linsheng...Deng, Jiedan;  Long, Lin;  Peng, Xue;  Jiang, Weifan;  Peng, Ying;  Zhang, Xi;  Zhao, Yuting;  Tian, Ying;  Wang, Zhen;  Zhuo, Linsheng
Favorite  |    Submit date：2023/07/18
Top 1  tubulin inhibitor  Evodiamine derivatives  Anti -Tumor  
Discovery of carbamate-based salicylic acid derivatives as novel cholinesterase inhibitor 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2023, 卷号: 1276
Authors:  Wang, Yuying;  Long, Lin;  Yu, Quanwei;  Zhang, Honghua;  Li, Xuelin;  Zhuo, Linsheng;  Wang, Shuzhi;  Wang, Zhen
Favorite  |    Submit date：2023/02/22
Cholinesterase inhibitor  Neuroprotective effect  Anti-apoptotic effect  Carbamate derivatives of salicylic acid  Docking  
Discovery of carbamate-based salicylic acid derivatives as novel cholinesterase inhibitor 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2023, 卷号: 1276
Authors:  Wang, Yuying;  Long, Lin;  Yu, Quanwei;  Zhang, Honghua;  Li, Xuelin;  Zhuo, Linsheng;  Wang, Shuzhi;  Wang, Z(王震)
Favorite  |    Submit date：2023/07/18
Hydrogen bonds  Mammals  Neurodegenerative diseases  Acid derivative  Alzheimers disease  Anti-apoptotic effects  Carbamate derivative of salicylic acid  Carbamate derivatives  Cholinesterase inhibition  Cholinesterase inhibitor  Docking  Neuroprotective effects  Synthesised  
Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor 期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
Authors:  Sun, Shouyuan;  Shi, Tao;  Peng, Yan;  Zhang, Honghua;  Zhuo, Linsheng;  Peng, Xue;  Li, Qien;  Wang, Manxia;  Wang, Shuzhi;  Wang, Zhen...Sun, Shouyuan;  Shi, Tao;  Peng, Yan;  Zhang, Honghua;  Zhuo, Linsheng;  Peng, Xue;  Li, Qien;  Wang, Manxia;  Wang, Shuzhi;  Wang, Zhen
Favorite  |    Submit date：2023/02/22
substituted pyrroles  acetylcholinesterase  butyrylcholinesterase  molecular docking  enzyme kinetic  
From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders 期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
Authors:  Wu, Junbo;  Zhang, Honghua;  Wang, Yuying;  Yin, Gaofeng;  Li, Qien;  Zhuo, Linsheng;  Chen, Hongjin;  Wang, Zhen
Favorite  |    Submit date：2023/02/22
carbamylated tryptamine derivatives  benzylation  promising building blocks  MTDLs  cholinesterase inhibitors  neuroprotection  anti-neuroinflammation  neurodegenerative disorders  
Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242
Authors:  Zhang, Honghua;  Peng, Yan;  Zhuo, Linsheng;  Wang, Yuying;  Zeng, Guo;  Wang, Shuzhi;  Long, Lin;  Li, Xuelin;  Wang, Zhen
Favorite  |    Submit date：2022/11/09
Alzheimer?s disease  Cholinesterase inhibition  A? modulation  Multifunctional agents